Изучение механизмов ограничения активности энхансеров D. melanogaster тема диссертации и автореферата по ВАК РФ 03.01.07, кандидат биологических наук Давыдова, Анна Игоревна

• Давыдова, Анна Игоревна
• кандидат биологических наук
• 2011

Введение диссертации (часть автореферата) на тему «Изучение механизмов ограничения активности энхансеров D. melanogaster»

Актуальность проблемы.8

Цель и задачи исследования.10

Научная новизна и практическая ценность работы.11

Апробация работы.11

Публикации.12

Заключение диссертации по теме «Молекулярная генетика», Давыдова, Анна Игоревна

выводы

1) Показано, что некодирующая транскрипция негативно влияет на активность энхансеров генов white и yellow.

2) Продемонстрировано, что терминаторы транскрипции стабилизируют функционирование энхансеров генов white и yellow в составе трансгенов.

3) Установлено, что 1А2- и Wari-инсуляторы функционально взаимодействуют с промоторами разных классов.

4) Выяснено, что обогащение белков CP 190 и Mod(mdg4)-67.2 на промоторе гена even-skipped зависит от присутствия 1 А2-инсулятора в трансгене.

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